Fig. 1
From: Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation
The dentate gyrus of TRPV4KO mice exhibits abnormal neuronal firing at physiological temperature. a Recording of field EPSPs (fEPSPs) at medial perforant path (MPP)-DG granule synapses near the cell bodies at 30 °C or 35 °C. Representative traces are shown in the top panels for both WT and TRPV4 hippocampal slices. The observed population spikes are indicated by arrowheads. The timing of the stimuli is shown by arrows. b The number of population spikes were quantified (n = 16 slices) at 30 °C or 35 °C. c The latency of the 1st population spike after the stimulus was quantified (n = 16 slices) at 30 °C or 35 °C. The asterisks represent statistical significance (p < 0.05) compared with the result at 30 °C in the same mouse strain group
