Fig. 4

TRPV4 contributes to hippocampal activity through its activation by brain temperature. a Representative EEG traces of WT or TRPV4KO hippocampal DGs under freely moving conditions. Local DG temperature was also measured, and was artificially lowered using the implanted cooling devices (indicated by the blue line). Green insets represent high magnifications of the basal DG EEG. Red insets represent high magnifications of the cooled DG EEG. b Representative EEG power spectrum of Figure A. The blue trace represents WT basal activity. The red trace represents TRPV4KO basal activity. The light green trace represents WT activity under cooling. The purple trace represents TRPV4KO activity under cooling. c: Quantification of EEG θ wave power spectra. d: Reduction of theta power under cooling conditions was calculated using an operation (basal – cooling), and the ratio was also quantified compared with WT results. The asterisks represent statistical significance (p < 0.05) compared with the WT group