Fig. 5
From: Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation
Brain temperature elevation at epileptogenic foci accelerates epileptic events. a We generated epileptic mice utilizing a hippocampal kindling method. After generating the mice, we confirmed the generations of model by epileptic discharge EEG patterns. b Quantification of hippocampal temperature in sham-operated (control) or kindling epileptic model mice (n = 6). The asterisks represent statistical significance (p < 0.01) compared with the control group. c, d Neuronal firing was recorded from acute hippocampal slices (n = 8) at the surgical sites at two different temperatures (C; 37 °C or D; 38 °C). e Quantification of firing frequency at two different temperatures (n = 8). The asterisks represent statistical significance (p < 0.01) compared with the 37 °C condition
