Fig. 6
From: Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation
Brain cooling suppresses epileptic discharges through inhibition of TRPV4. a Representative EEG traces of WT or TRPV4KO epileptic mice, whose epilepsy was evoked by local injection of kainic acid (0.1 μl of a 3 mg/ml kainite solution) into the hippocampus. The brain-cooling devices were also placed into the DGs, then the kainite-induced epileptogenic foci were cooled. Local DG temperature was also measured. b, c Quantification of the number (B) or amplitude (C) of epileptic discharges under basal or cooling conditions in WT or TRPV4KO epileptic mice (n = 6). The asterisk represents statistical significance (p < 0.01) compared with the WT basal condition. The hash mark represents statistical significance (p < 0.01) compared with the WT basal condition
