Fig. 7
From: Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation
A TRPV4-specific inhibitor suppresses epileptic discharges. a Representative EEG traces of WT or TRPV4KO epileptic mice, whose epilepsy was evoked by kindling treatment into the hippocampus. Local injection of HC067047 (a TRPV4-specific inhibitor) into the epileptogenic foci was performed during EEG recordings. b, c Quantification of the number (B) or amplitude (C) of epileptic discharges under basal or HC067047-injected conditions in WT or TRPV4KO epileptic mice (n = 6). The asterisk represents statistical significance (p < 0.05) compared with the WT basal condition. The hash mark represents statistical significance (p < 0.05) compared with the WT basal condition
