Fig. 6 | Laboratory Investigation

Fig. 6

From: Vascular endothelial growth factor enhances profibrotic activities through modulation of calcium homeostasis in human atrial fibroblasts

Fig. 6

The effects of ethylene glycol tetra-acetic acid (EGTA) on vascular endothelial growth factor (VEGF) increased profibrotic signaling in atrial fibroblasts. Photographs and averaged data show the pro-collagen type I production (n = 5 independent experiments), pro-collagen type III production (n = 7 independent experiments), α-smooth muscle actin (SMA, n = 7 independent experiments), phosphorylated Ca2+/calmodulin-dependent protein kinase II (pCaMKII, n = 6 independent experiments), and total CaMKII (tCaMKII, n = 6 independent experiments) in VEGF-treated (1000 pg/mL) atrial fibroblasts with or without EGTA (1 mmol/L) for 48 h. GAPDH was used as a loading control. *p < 0.05, ***p < 0.005

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