Fig. 3: Limbal neovascularization in a S1PR3-null mouse. | Laboratory Investigation

Fig. 3: Limbal neovascularization in a S1PR3-null mouse.

From: Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea

Fig. 3

Flat-mounted specimen of the treated corneas suggests that S1PR3 gene deletion suppressed development of neovascularization as compared with a wild-type (WT) mouse at day 7. a In an uninjured WT mouse cornea, CD31-labeled vessels do not penetrate into the cornea interior. b In a WT cornea at day 7 post-cauterization CD31-labeled vessels do not extend into the cornea sprouts (arrowheads). c Such sprouts of the vessels are not observed in a KO post-cauterization cornea. Circled numbers 1–4 in the bottom two rows provide higher magnification images of the aforementioned described boxed in areas shown in each of Frames a, b and c. Bar, 1000 μm.

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