Fig. 8: Roles of S1PR3 signaling in mediating the expression of VEGF-A mRNA in TKE2 corneal epithelial cell line and primary ocular fibroblasts. | Laboratory Investigation

Fig. 8: Roles of S1PR3 signaling in mediating the expression of VEGF-A mRNA in TKE2 corneal epithelial cell line and primary ocular fibroblasts.

From: Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea

Fig. 8

Both TKE2 corneal epithelial cells (a) and primary ocular fibroblasts (b) express S1PR3. Scale Bar, 200 μm. Administration of S1P upregulated VEGF-A, that declined following addition of an S1PR3 antagonist, CAY10444 (c). On the other hand, administration of S1P and/or CAY10444 did not affect the expression level of VEGF-A in ocular fibroblasts (d).

Back to article page