Fig. 7: Correlation of PAI-1 and LRP1 expression in esophageal squamous cell carcinoma (ESCC) tissues with the prognosis of ESCC patients. | Laboratory Investigation

Fig. 7: Correlation of PAI-1 and LRP1 expression in esophageal squamous cell carcinoma (ESCC) tissues with the prognosis of ESCC patients.

From: PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages

Fig. 7

a Kaplan–Meier analysis of ESCC patients divided into two groups according to PAI-1 expression: PAI-1 Low group (n = 42) and PAI-1 High group (n = 26). The log-rank test was performed to determine significance (*p < 0.05). b Kaplan–Meier analysis of ESCC patients divided into two groups according to LRP1 expression in cancer nest: LRP1 Low group (n = 40) and LRP1 High group (n = 28). The log-rank test was performed to determine significance (*p < 0.05). c Kaplan–Meier analysis of ESCC patients divided into two groups according to LRP1 expression in the stroma: LRP1 Low group (n = 27) and LRP1 High group (n = 41). The log-rank test was performed to determine significance (*p < 0.05). d Kaplan–Meier analysis of ESCC patients divided into three groups based on the combination of the immunoreactive intensity of PAI-1 in the stroma and LRP1 in cancer nest (CA), as follows: PAI-1 Low/LRP1 (CA) Low (n = 24); PAI-1 Low/LRP1 (CA) High and PAI-1 High/LRP1 (CA) Low (n = 34); PAI-1 High/LRP1 (CA) High (n = 10). The log-rank test was performed to determine significance (*p < 0.05, **p < 0.01). e Kaplan–Meier analysis of ESCC patients divided into three groups based on the combination of the immunoreactive intensity of PAI-1 and LRP1 in the stroma (ST), as follows: PAI-1 Low/LRP1 (ST) Low (n = 21); PAI-1 Low/LRP1 (ST) High and PAI-1 High/LRP1 (ST) Low (n = 27); PAI-1 High/LRP1 (ST) High (n = 20). The log-rank test was performed to determine significance (*p < 0.05, **p < 0.01). CA, cancer nest. ST, stroma.

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