Fig. 2: Upregulation of folliculogenic factors at the mRNA and protein levels after PD-MSC transplantation. | Laboratory Investigation

Fig. 2: Upregulation of folliculogenic factors at the mRNA and protein levels after PD-MSC transplantation.

From: Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway

Fig. 2: Upregulation of folliculogenic factors at the mRNA and protein levels after PD-MSC transplantation.The alternative text for this image may have been generated using AI.

a mRNA expression levels of Nanos3, Lhx8, Lin28α, Nobox, Bmp15, and Egfr were decreased in the NTx groups compared to the normal group and increased in the Tx groups compared to the NTx groups with some exceptions. b Western blot analysis showed an overall increase in the expression level in the Tx groups compared to the NTx groups with some exceptions. c Immunohistochemistry for LHX8 showed higher folliculogenic activity after Tx. PD-MSCs, treatment group. *vs. the normal group (P < 0.05). #, vs. NTx (P < 0.05). Nor, normal group. NTx, non-transplantation group. Tx, transplantation group. 1w, week 1. 2w, week 2. 3w, week 3. 5w, week 5.

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