Fig. 2: Suppression of miR-181a-5p reduced mossy fiber sprouting and alleviated neuronal loss in the hippocampus. | Laboratory Investigation

Fig. 2: Suppression of miR-181a-5p reduced mossy fiber sprouting and alleviated neuronal loss in the hippocampus.

From: Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy

Fig. 2

a Mossy fiber sprouting in the hippocampus of different animal groups observed by Timm’s staining. Scale bar, 50 μm. b Timm’s staining was evaluated and presented as Timm’s scores. c H&E staining of the hippocampal neurons after SE induction. Scale bar, 100 μm. d The numbers of the neurons observed by H&E staining. e The images of Nissl staining for Nissl bodies (blue/violet). Scale bar, 100 μm.f The numbers of Nissl bodies were counted. The data in panels (b, d and f) are shown as the mean ± SD and were analyzed by one-way ANOVA with Tukey’s test for multiple comparisons (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).

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