Fig. 5: MiR-126-5p directly targets both mus and homo VEPH1 mRNA. | Laboratory Investigation

Fig. 5: MiR-126-5p directly targets both mus and homo VEPH1 mRNA.

From: MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice

Fig. 5

The sequence information of wild and mutant types of VEPH1 mRNA was shown in a. Dual-luciferase reporter assay was performed to analyze the binding between miR-126-5p and VEPH1 (b, c). Luciferase ratio of the first repetition of cells transfected with VEPH1 wild-type plasmid and NC agomirs (VEPH1 wild type + NC agomirs) was normalized as 1. VEPH1 ventricular zone expressed PH domain containing 1, NC negative control. *, <0.05; **, <0.01; ***, <0.001 (n = 5).

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