Fig. 6: Hepatic gene expression signature for the biliatresone-induced mouse model of BA at 14 days post injection. | Laboratory Investigation

Fig. 6: Hepatic gene expression signature for the biliatresone-induced mouse model of BA at 14 days post injection.

From: The synthetic toxin biliatresone causes biliary atresia in mice

Fig. 6

KEGG pathway (a) and GO enrichment analysis (b) of differentially expressed genes (DEGs) by RNA-seq in the liver of BA and control mice. Heat map of the overexpression of Vcan, Ccl20, Vtcn1, Itga2, Serpine1, Thbs1, Ccl2, Lamc2, Areg, Slc2a3, Mmp7, and Cxcl1, Cxcl2, and Cxcl5 from hepatic DEGs (c). mRNA expression of Itga2, Serpine1, Thbs1, Ccl2, Mmp7, Cxcl2 Cxcl5, and Cxcl1 in the liver of BA and control mice (d). Heat map of the expression of GSH metabolism-related genes from hepatic DEGs (e). mRNA expression of gclm, gclc, gsto2, gsta3 by RT-qPCR. Levels of hepatic GSH in BA and control mice at 14 days post injection (f). **p < 0.01, ***p < 0.001. BP biological process, CC cellular component, MF molecular function.

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