Fig. 4: Single-cell RNA-sequencing demonstrates a single population of gallbladder epithelial cells expressing CFTR. | Laboratory Investigation

Fig. 4: Single-cell RNA-sequencing demonstrates a single population of gallbladder epithelial cells expressing CFTR.

From: Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model

Fig. 4: Single-cell RNA-sequencing demonstrates a single population of gallbladder epithelial cells expressing CFTR.

t-SNE plots of single-cell RNA-sequencing. Different cell types collected from luminal scraping of the gallbladder epithelium. Each symbol correlates to a single cell while the coloring of each cell represents the cell type grouping (indicated by the text in the same color). CFTR expression correlates with epithelial cells. MUC5AC and MUC5B were highly expressed in the same epithelial cells expressing CFTR. MUC2 and MUC6 were not highly expressed in the epithelial cell population. Each symbol represents a single cell and the hue of each symbol represents the expression level for that gene.

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