Fig. 5: Gene Cluster Expression Summary Scoring (GCESS) analyses to identify like clusters in distinct gene expression databases. | Laboratory Investigation

Fig. 5: Gene Cluster Expression Summary Scoring (GCESS) analyses to identify like clusters in distinct gene expression databases.

From: Retinoblastoma tumor cell proliferation is negatively associated with an immune gene expression signature and increased immune cells

Fig. 5

Comparison of our identified clusters with those from several other mouse developmental or mouse and human retinoblastoma studies. A Clusters of genes identified in our RNA-Seq transcriptional data are displayed as heatmaps with yellow showing increased transcription and blue decreased transcript levels. B Gene expression pattern comparisons with a mouse retinal development timecourse (GSE87043). C A human retinoblastoma dataset (GSE29683) -Y79 and Weri1 human retinoblastoma cell lines; -human patient derived xenograft samples and D a mouse retinoblastoma dataset (GSE29685). Each of the five clusters identified by our RNA-seq analyses are marked with color coded sidebars to the right of the heatmap, and their identifiers are shown below. -ΔRb/p107/p130-deficient murine tumors. Color-coded clusters in related cross-species databases denote shared genes at a highly significant level (p < 1e−5).

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