Fig. 6: Intratumor comparisons between cell cycle, differentiation, and immune signature summary scores for retinal and retinoblastoma transcriptional datasets. | Laboratory Investigation

Fig. 6: Intratumor comparisons between cell cycle, differentiation, and immune signature summary scores for retinal and retinoblastoma transcriptional datasets.

From: Retinoblastoma tumor cell proliferation is negatively associated with an immune gene expression signature and increased immune cells

Fig. 6

Analysis of cell-cycle, differentiation, and immune Gene Cluster Expression Summary Scoring (GCESS) scores to determine intra-tumor gene expression pattern relationships in related cross-species developmental and retinoblastoma datasets. Cell cycle versus Differentiation GCESS scores were compared within A our full dataset, B only the early-onset tumors from our dataset, C the mouse retinal developmental dataset (GSE87043), D mouse RB tumors (GSE29685), and E human RB tumors (GSE29683). Intratumor comparison between Cell cycle and immune GCESS scores for F early-onset tumors from our dataset, G mouse RB tumors (GSE29685), and H human RB tumors (GSE29683).

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