Fig. 3: Detecting biomarkers of disease and host response. | Laboratory Investigation

Fig. 3: Detecting biomarkers of disease and host response.

From: Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

Fig. 3

Heatmap of 25 differentially expressed dog transcripts (A) and 38 differentially expressed mouse transcripts (B) identified by statistical testing with ‘DESeq2’. Colored toe bars represent the different experimental samples. Asterisks in (A) indicate the genes incorporated into the osteosarcoma gene signature. The color-coded (red to blue) scale represents ±change gene expression. C Pathways identified by Ingenuity® Pathway Analysis as being associated with differentially expressed host (mouse) genes.

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