Fig. 6: PYR10 significantly reduced the absolute value of the INCX in bladder SMCs. | Laboratory Investigation

Fig. 6: PYR10 significantly reduced the absolute value of the INCX in bladder SMCs.

From: Increased transient receptor potential canonical 3 activity is involved in the pathogenesis of detrusor overactivity by dynamic interaction with Na+/Ca2+ exchanger 1

Fig. 6

a, b SEA0400 significantly inhibited the absolute value of the INCX density in bladder SMCs (10 μM, n = 5). c, d DMSO had no significant influence on the absolute value of the INCX in SMCs from control rats (n = 4). e, f DMSO had no significant influence on the absolute value of the INCX in SMCs from DO rats (n = 5). g, h The absolute value of the INCX density was significantly enhanced over a voltage range of −100 to −50 mV (forward mode) and at 0 to +60 mV (reverse mode) in SMCs from DO rats (n = 5) compared with SMCs from control rats (n = 6). The enhancement in the absolute value of the INCX density in SMCs in the reverse mode of NCX (+60 mV) was more significant than that in the forward mode of NCX (−100 mV) in DO rats. g, i, j PYR10 (100 nM) significantly reduced the absolute value of the INCX density in SMCs from control (n = 6) and DO rats (n = 5). The reduction in the absolute value of the INCX density in SMCs in the reverse mode of NCX (+60 mV) was more significant than that in the forward mode of NCX (−100 mV) in DO rats. *P < 0.05, **P < 0.01.

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