Table 1 Effect of YAP/TAZ knockdown on chemokine expression after mechanical loading evaluated by RNAseq.

From: Mechanical loading activates the YAP/TAZ pathway and chemokine expression in the MLO-Y4 osteocyte-like cell line

 

Control loading phenotype

YAP silencing under compression

TAZ silencing under compression

Gene

Log2FC

P adj.

Log2FC

P adj.

Log2FC

P adj.

Cxcl1

5.61

2.21E-68

0.08

0.99

0.13

0.99

Cxcl2

10.34

1.94E-111

0.07

0.99

−0.07

0.99

Cxcl3

5.29

9.07E-59

−0.33

0.99

−0.63

0.99

Cxcl9

4.11

1.7E-02

−3.28

0.99

−1.32

0.99

Cxcl10

2.01

7.09E-02

−0.43

0.99

−0.31

0.99

M-CSF

1.01

1.19E-02

−0.60

0.99

−0.89

0.99

  1. Chemokine gene levels were analyzed by RNAseq from MLO-Y4 cells invalidated for YAP/TAZ and submitted to mechanical loading. Data are presented as log2 fold change to analyze the effect of (A) loading (shControl loaded/shControl unloaded), (B) YAP silencing under mechanical loading (shYAP loaded/shControl loaded) and (C) TAZ silencing under mechanical loading (shTAZ loaded/shControl loaded). Data are the mean ± SEM of two independent experiments and its associated p value.