Fig. 7: Comparison between RDN and SGLT2i on the effect of DCM. | Laboratory Investigation

Fig. 7: Comparison between RDN and SGLT2i on the effect of DCM.

From: Renal denervation ameliorates cardiac metabolic remodeling in diabetic cardiomyopathy rats by suppressing renal SGLT2 expression

Fig. 7

A RDN was not inferior to SGLT2i in improving cardiac diastolic function. a Representative tracings of echocardiography. b LAD. c E/A ratio. d E/E’ ratio. B RDN was not inferior to SGLT2i in delaying cardiac pathological remodeling. a Representative images of WGA staining (magnification, ×400), HE staining (magnification, ×400) and Masson staining (magnification, ×400) in the hearts. b HW/BW ratio. c Quantitative analysis of myocyte size calculated from WGA staining. (d) Quantitative analysis of CVF calculated from Masson staining. (P < 0.05; n = 6, 10, and 8 in the DCM, RDN and SGLT2i groups, respectively; five sections were randomly selected per sample.) *P < 0.05 vs. the DCM group. LAD left atrial diameter, WGA wheat germ agglutinin, CVF collagen volume fraction.

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