Fig. 4: Histological changes induced by tazemetostat. | Laboratory Investigation

Fig. 4: Histological changes induced by tazemetostat.

From: Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies

Fig. 4

A Schematic illustration of the timing of mouse brain collection after in vivo treatment. B H&E staining showing the in vivo growth of PDOX tumors (*) from low (4×) to high (40×). Compared with the untreated control, the remnant tumor of IC-L1115ATRT remained highly invasive although the number of satellite foci (red arrowhead) was slightly reduced (upper panel). The local invasion of IC-1078MB was not significantly affected (lower panel). Cell proliferation (Ki-67) in the remnant tumor was similar to the untreated controls.

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