Fig. 2: Overexpression of CPT1A promotes the differentiation of GSCs. | Laboratory Investigation

Fig. 2: Overexpression of CPT1A promotes the differentiation of GSCs.

From: Overexpression of carnitine palmitoyltransferase 1A promotes mitochondrial fusion and differentiation of glioblastoma stem cells

Fig. 2: Overexpression of CPT1A promotes the differentiation of GSCs.

a Immunoblot analysis of CPT1A, GFAP, OLIG2, and SOX2 in NC or CPT1A-overexpression (CPT1A-OE) GSCs derived from GBM1 and GBM2. b Immunoblot analysis of CPT1A, GFAP, OLIG2, and SOX2 in NSTCs with or without CPT1A-knockdown (sh1-CPT1A and sh2-CPT1A). c Tumor-sphere formation assay of GSCs overexpressing CPT1A or not. d Quantification of tumor-sphere number and diameter of the GSCs overexpressing CPT1A or not. Experiments were independently performed for at least three times. **p < 0.01.

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