Fig. 2: CTLA-4 immunostaining of normal tissues. | Laboratory Investigation

Fig. 2: CTLA-4 immunostaining of normal tissues.

From: Semi-automated validation and quantification of CTLA-4 in 90 different tumor entities using multiple antibodies and artificial intelligence

Fig. 2

The panels show for the antibody MSVA-152R a strong membranous positivity of a subset of lymphocytes in the tonsil (A), a strong cytoplasmatic staining of the adrenal cortex (B) and a cytoplasmic granular staining in a fraction of superficial epithelial cells of the stomach (C) and of renal tubuli (D). For the antibody CAL49, a strong membranous positivity of the same subset of lymphocytes in the tonsil (E), a weak cytoplasmatic staining of the adrenal medulla (F), a strong cytoplasmic staining superficial epithelial cells of the stomach (G), and an apical membranous staining of renal tubuli (H) is seen. The images (A–D) and (E–H) are from consecutive tissue sections and taken at 20x magnification.

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