Fig. 1: DNMT1 is upregulated and miR-152-3p is downregulated in the rat heart failure model, exhibiting an inverse correlation. | Laboratory Investigation

Fig. 1: DNMT1 is upregulated and miR-152-3p is downregulated in the rat heart failure model, exhibiting an inverse correlation.

From: DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis

Fig. 1

A Representative H&E images displaying the histological characteristics of heart tissues from control rats and DOX-treated rats. Scale bar = 50 μm. Arrowhead indicates neutrophils. B Relative expression of DNMT1 in heart tissues from control rats and DOX-treated rats determined by RT-qPCR. C DNMT1 protein expression in heart tissues from control rats and DOX-treated rats determined by western blot analysis. D Expression of miR-152-3p in heart tissues from control rats and DOX-treated rats determined by RT-qPCR. E Pearson’s correlation analysis evaluating the relationship between DNMT1 expression and miR-152-3p expression in heart tissues from DOX-treated rats. *p < 0.05, compared to control rats. n = 10 rats in each group.

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