Fig. 3: More leukocytes, predominately myeloid cells, accumulate in the synovium of IL-34 KO and PTPRZ KO with K/BxN serum-transfer arthritis versus WT mice. | Laboratory Investigation

Fig. 3: More leukocytes, predominately myeloid cells, accumulate in the synovium of IL-34 KO and PTPRZ KO with K/BxN serum-transfer arthritis versus WT mice.

From: IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice

Fig. 3

A Experimental scheme for the analysis of leukocytes subsets in IL-34 KO versus WT in synovial tissue. B–G Synovial tissue was analyzed and compared in IL-34 KO and WT mice after the induction of arthritis (day 10) using relevant markers by flow cytometry. Representative of four similar experiments. B Number of leukocytes. Number and frequency of (C) myeloid cells, (D) neutrophils, (E) Mø, (F) T cells, and (G) B cells in IL-34 KO and WT synovium. H Experimental scheme for the analysis of leukocytes subsets in PTPRZ KO versus WT in synovial tissue. I–N Synovial tissue analyzed in PTPRZ KO and WT mice after the induction of arthritis (day 10) by flow cytometry. Representative of four similar experiments. I Number of leukocytes. Number and frequency of (J) myeloid cells, (K) neutrophils, (L) Mø, (M) T cells, and (N) B cells in PTPRZ KO and WT synovium. Data are represented as the means ± SEM (n = 5/group). *P < 0.05. **P < 0.01; two-tailed, Mann–Whitney U test.

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