Table 2 Multivariate Cox proportional hazards regression analysis of overall and disease-free survival in patients with oral squamous cell carcinoma (n = 110).

From: The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation

  

OS

DFS

Variables

Assigned score

Hazard ratio (95% CI)

p value

Hazard ratio (95% CI)

p value

Age, years

  ≤65

0

0.852 (0.354–2.024)

0.716

1.200 (0.556–2.614)

0.642

  >65

1

    

Sex

  Male

0

0.792 (0.352–1.747)

0.564

0.873 (0.419–1.791)

0.712

  Female

1

    

Primary site

  Tongue

1

0.922 (0.710–1.181)

0.527

1.065 (0.421–2.614)

0.892

  Mandible

2

    

  Maxilla

3

    

  Oral floor

4

    

  Buccal mucosa

5

    

pT-stage

  T1, T2

1

1.098 (0.716–1.700)

0.668

2.263 (0.710–7.492)

0.168

  T3

2

    

  T4

3

    

pN-stage

  N = 0

0

3.526 (1.643–8.030)

0.001**

2.822 (1.421–5.781)

0.003**

  N ≥ 1

1

    

Differentiation

  Well

0

1.015 (0.424–2.250)

0.923

1.035 (0.445–2.194)

0.933

  Moderate

1

    

Pathological response

  Grade = 0, I, IIa

0

0.284 (0.123–0.659)

0.004**

0.331 (0.158–0.711)

0.005**

 Grade ≧ IIb

1

    

p-Nrf2 status

  Low

0

2.224 (1.070–4.747)

0.032*

2.039 (1.041–4.041)

0.038*

  High

1

    
  1. CI confidence interval, OS overall survival, DFS disease-free survival.
  2. *p < 0.05; **p < 0.01.
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