Fig. 1: Whole exome sequencing of the original lymphoma cells obtained from patient P1 and the derived PDX model VFN-D3.
From: Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas
A A circular ideogram showing the predicted copy number variants (CNVs) for the patient’s sample (P1) and the corresponding PDX model (D3). Outer track represents chromosomal positions of the predicted CNVs. Gene deletions are marked in shades of blue (“1”: predicted monoallelic deletion, “0”: predicted biallelic deletion). Gene amplifications are marked in shades of red (“3”: gain of 1 allele, “>3”: gain of more than 1 allele). Graphical table at the center is showing CNV of genes of special interest. B Scatter plot showing the allele frequency of shared, newly-detected (N/D), and newly-undetected (N/U) variants in the PDX model sample compared to the sample from which it was derived. Labels show variants found in genes of special interest for the analyzed lymphoma subtype, described in the methods. C Stacked bar plot showing numbers of shared, N/D and N/U variants in the patient and the PDX sample. P patient sample, CN copy number, CTRL germline control DNA from patient, N number.
