Fig. 3: Consistently observed phenotypic alterations between primary lymphoma biopsies and the derived PDX tumors.
From: Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas
A More blastoid morphology of PDX cells compared to patients´ primary lymphoma cells; B Increased proliferation rate by Ki-67 in PDX cells compared to patients´ original lymphoma cells; C Lack of T-lymphocytes in the PDX TME; D Lack of both human and murine macrophages in PDX TME; presence of murine macrophages in murine spleen; E Lack of vessels of human origin; presence of vessels of murine origin in the PDX TME; F Significantly lower microvessel density (MVD) and microvessel area (MVA) in PDX tumors compared to original patients´ lymph node biopsies; Y axis in MVD displays number of vascular profiles per 1 mm2 of the tumor; Y axis in MVA displays microvessel area as area fraction (per mill, ‰) of the total area of CD31-positive microvessel profiles within the tumor; the data are displayed as means, bars show the standard deviations.“. For more detailed information, see also Supplementary Tables 2 and 3.
