Table 1 Baseline characteristics of the analyzed samples.

From: Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas

Pt

Gender

Dg

Subtype

Disease status

Sample origin

WES

Therapy

PDX

1

F

DLBCL

non-GC

Dg

LN

Yes

Untreated

VFN-D3

2

M

DLBCL

non-GC

Dg

LN

Yes

Untreated

VFN-D6

3

M

DLBCL

non-GC

R/R

LN

Yes

G-CHOP

VFN-D1

4

M

DLBCL

GC

R/R

EN (soft tissues)

Yes

R-CHOP + venetoclax; R-ESHAP; R-GIFOX; RT

VFN-D4

5

F

DLBCL

non-GC

R/R

LN

Yes

R-CHOP; R-ESHAP; R-GIFOX; RT

VFN-D5

6

M

tDLBCL

GC, transformed from MZL

Dg

LN

No

R-COP

VFN-D12

7

F

DLBCL

double-hit

R/R

LN

Yes

R-CHOP / R-ESHAP

VFN-D20

8

M

Burkitt

 

R/R

EN (stomach)

Yes

R-Hyper-CVAD, R-MTX-HD-araC

VFN-B3

9

M

MCL

 

R/R

LN

Yes

Nordic protocol

VFN-M5R1

10

F

MCL

 

R/R

LN

Yes

Nordic protocol

VFN-M1

11

M

AITL

 

R/R

LN

Yes

CHOEP

VFN-T3

12

F

AITL

 

R/R

LN

No

Untreated

VFN-T7

13

F

PTCL, NOS

 

R/R

LN

Yes

CHOEP

VFN-T6

14

M

ALCL

ALK-negative

Dg

LN

Yes

Untreated

VFN-T5

15

M

ALCL

ALK-positive

Dg

LN

Yes

Untreated

VFN-T4

  1. AITL angioimmunoblastic T-cell lymphoma, ALCL anaplastic large cell lymphoma, ALK anaplastic lymphoma kinase, araC cytarabine, COP cyclophosphamide; vincristine; prednisone, CHOP COP + doxorubicin, CHOEP CHOP + etoposide, Dg diagnosis, DLBCL diffuse large B-cell lymphoma, EN extra-nodal, ESHAP etoposide; solumedrole; high-dose araC; cisplatin, FL follicular lymphoma, G-CHOP obinutuzumab plus CHOP, GC germinal center, GIFOX gemcitabine; ifosfamide; oxaliplatin, HD-araC high dose araC, hyperCVAD hyperfractionated cyclophosphamide; doxorubicin, vincristine; dexamethasone, LN lymph node, MCL mantle cell lymphoma, MZL marginal zone lymphoma, MTX methotrexate, Pt patient, PTCL peripheral T-cell lymphoma, R rituximab, RM rituximab maintenance, R/R relapsed, RT radiotherapy, tDLBCL transformed DLBCL.