Table 2 Median allele frequencies and types of somatic mutations newly detected or undetected in PDX models.

A.	Median AF of N/D mutations in PDXs	Median AF of N/U mutations in patient samples
All PDX models	0.18	0.15
DLBCL	0.27	0.14
MCL	0.18	0.36
T-NHL	0.15	0.14
BL^a	0.17	0.11
B.	N/D from the Gene-list	N/U from the Gene-list
VFN-D1 vs P3	ETV6	RUNX1
VFN-D3 vs P1	PDGFRA	0
VFN-D4 vs P4	NF1, HIPK3	0
VFN-D5 vs P5	ITPKB, ENAM	0
VFN-D6 vs P2	IRF4, RNF213, MYC, FOXO1, KLHL14, KLHL14, OSBPL10	0
VFN-D20 vs P7	0	0
VFN-M1 vs P10	0	0
VFN-M5R1 vs P9	0	0
VFN-T3 vs P11	STAT1, ZNF708, RHOA	0
VFN-T4 vs P15	SPEN, FSIP2, DCC, ZNF532	0
VFN-T5 vs P14	AIRD1B, VPS13A, MYD88	0
VFN-T6 vs P13	IRF2BP2, VAV1, TCF20	BIRC6
VFN-B3 vs P8	0	0

A Median allele frequencies (AF) of newly detected (N/D) mutations in PDX models and newly undetected (N/U) mutations in primary lymphoma samples, B N/D and N/U variants from the list of genes of special interest (Gene-list), 0 no gene list variant, BL Burkitt lymphoma, DLBCL diffuse large B-cell lymphoma, MCL mantle cell lymphoma, P1-P15 patient primary lymphoma samples, T-NHL T-cell non-Hodgkin lymphomas, VFN PDX models derived from primary lymphoma samples P1-P15.
^aOnly 1 PDX model.

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