Fig. 4: OVX-induced bone loss was enhanced in OCZF-Tg mice. | Laboratory Investigation

Fig. 4: OVX-induced bone loss was enhanced in OCZF-Tg mice.

From: Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68

Fig. 4

A µCT images of the distal femurs of WT and OCZF-Tg female mice (12-week-old). Representative µCT reconstructions of horizontal (left) and vertical (right) views of trabecular bones are shown. (Left, sham-operated, Right, OVX-operated.) B Bone structure analysis of the distal metaphyseal femurs of WT (n = 5) and OCZF-Tg mice (n = 4). Trabecular bone parameters: bone volume per total volume (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N). C Cortical bone structure analysis of the central diaphyseal portions of femurs of WT (n = 5) and OCZF-Tg mice (n = 4). All data are presented as the mean ± SD. The statistical differences between mean values were determined by one-way ANOVA followed by Tukey’s post hoc test in (B, C). **P < 0.01, *P < 0.05.

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