Fig. 4: Pattern of expression and distribution of Siglec-15 in HNSCC (YTMA 465). | Laboratory Investigation

Fig. 4: Pattern of expression and distribution of Siglec-15 in HNSCC (YTMA 465).

From: Quantitative assessment of Siglec-15 expression in lung, breast, head, and neck squamous cell carcinoma and bladder cancer

Fig. 4

A Dynamic range of Siglec-15 expression in tumor. B Dynamic range of Siglec-15 expression in stroma. C Representative images of Siglec-15 tumor mask. D Representative images of Siglec-15 stromal mask. E, F Regressions between different blocks (tumoral heterogeneity) in tumor (E) and stroma (F). G, H Regressions between serial sections in tumor (G) and stroma (H). I Correlation of Siglec-15 between tumor and stroma. Association of Siglec-15 with PD-L1 in HNSCC. J–M Representative images of Siglec-15 expression on the left and PD-L1 on the right. N, O Correlation between Siglec-15 and PD-L1 in tumor (N) and stroma (O).

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