Fig. 5: GTSE1 knockdown suppresses tumor growth and metastasis in vivo. | Laboratory Investigation

Fig. 5: GTSE1 knockdown suppresses tumor growth and metastasis in vivo.

From: GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma

Fig. 5: GTSE1 knockdown suppresses tumor growth and metastasis in vivo.

A (Left) Representative bioluminescent images of nude mice undergone orthotopic implantation with Luc-labeling SN12-PM6 cells stably transfected by control shRNA or shGTSE1. (Right) Tumors were resected on 4 weeks and measured. B Histopathological analysis of the tumors in the shGTSE1 and control group. C Representative hematoxylin & eosin staining of lung tissues from the different groups. D (Left) Representative IHC staining images of GTSE1 and Ki-67 for primary renal tumors. The scale bar represents 20 μm. (Right) Quantitative analyses for Ki-67 positive SN12-PM6 cells stably expressing control shRNA or shGTSE1.

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