Fig. 5: Pathway and Gene Ontology analysis of RNAseq results. | Laboratory Investigation

Fig. 5: Pathway and Gene Ontology analysis of RNAseq results.

From: Oncogenic potential of PIK3CD in glioblastoma is exerted through cytoskeletal proteins PAK3 and PLEK2

Fig. 5

A Heatmap showing all the gene expressions (log2(x + 1)) in U87, SD2 and SD13. The orange color represents up-regulated genes and the blue represents down-regulated genes. Clustering was performed using complete method based on the Euclidean distance. B The Venn plots show the overlapped up-/down-regulated DEGs between U87-vs-SD2 and U87-vs-SD13. The 1125 up- and 1822 down-overlapped regulated DEGs were ranked with the average log2FC of U87-vs-SD2 and U87-vs-SD13. C The overlapped DEGs are respectively enriched in top 5 biological processes, cellular components and molecular functions based on the gene ontology enrichment analysis. The different dot size represents the different enriched gene count. D PPI network of DEGs in axonogenesis pathway. The PIK3CD and PAK nodes are highlighted in red.

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