Fig. 4
From: Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration
Expression of PI3Kγ subunits in malignant B cell lines and CLL patient samples. a, b CLL cells were stimulated with F(ab′)2 α-IgM (10 µg/ml) or CD40L/IL-4 (50 ng/ml each) and harvested 24 h later for RNA extraction and RT-qPCR analysis. mRNA expression of a p110γ and b p101 were determined, and expression levels were normalized against the expression of TATA box-binding protein (TBP). Patients were divided into indolent vs. progressive groups based on IgVH mutation status. c Protein expression of p110γ and p101 in CLL samples in response to BCR stimulation or CD40L/IL-4 stimulation. Data are representative of nine patients analyzed
