Table 1 Overall results of the chromothripsis analysis in 8q22.3–24.1 regions

From: MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences

Sample

Clustering of breakpoints

Randomness of fragment joins/randomness of segment order

Ability to walk the derivative chromosome

Regularity of oscillating copy number state

Interspersed regions with loss and retention of heterozygosity

MLL_11929

Y

N/Y

N

Not oscillating, >3 states

Unmatching LOH and CN loss

MLL_10598

Y

N/Y

N

Oscillating, >3 states

Unmatching LOH and CN loss

MLL_11930

Y

N/Y

N

Not oscillating, >3 states

Unmatching LOH and CN loss

MLL_11931

Y

N/Y

N

Not oscillating, 3 states

Unmatching LOH and CN loss

MLL_12445

Y

N/Y

N

Not oscillating, 3 states

Unmatching LOH and CN loss

MLL_10619

Y

N/Y

N

Not oscillating, 3 states

Unmatching LOH and CN loss

MLL_11932

Y

N/Y

N

Not oscillating, <3 states

Unmatching LOH and CN loss

MLL_11933

Y

N/Y

N

Not oscillating, 3 states

Unmatching LOH and CN loss

MLL_11934

Y

N/Y

N

Not oscillating, 3 states

Unmatching LOH and CN loss

MLL_11935

Y

N/Y

N

Oscillating, >3 states

Unmatching LOH and CN loss

MLL_11936

Y

N/Y

N

Not oscillating, >3 states

Unmatching LOH and CN loss

MLL_11937

Y

N/Y

N

Not oscillating, 3 states

Unmatching LOH and CN loss

MLL_11938

Y

N/Y

N

Oscillating, >3 states

Unmatching LOH and CN loss

MLL_11939

Y

N/Y

N

Oscillating, >3 states

Unmatching LOH and CN loss

MLL_11940

Y

N/Y

N

Not oscillating, 2 states

Unmatching LOH and CN loss

MLL_11941

Y

N/Y

N

Not oscillating, >3 states

Unmatching LOH and CN loss

07B60

N

N/Y

N

Oscillating, >3 states

Unmatching LOH and CN loss

1262-09

Y

N/Y

N

Oscillating, >3 states

Unmatching LOH and CN loss

757-02

Y

N/Y

N

Not oscillating, >3 states

Unmatching LOH and CN loss

756-04

Y

N/Y

N

Not oscillating, 3 states

Unmatching LOH and CN loss

1-07KM6821

Y

N/Y

N

Oscillating, >3 states

Unmatching LOH and CN loss

3-06PB4872

Y

N/Y

N

Not oscillating, 3 states

Unmatching LOH and CN loss

4-09KM0664

Y

N/Y

N

Not oscillating, >3 states

Unmatching LOH and CN loss

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