Table 4 Comparison of unadjusted CR rates of patients with medullary relapsed/refractory ALL between two sequential TACL studies

From: Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study

Number of salvage attempt

CR rate (SE)

[95% confidence interval]

Difference (Sun–Ko) (SE)

(testing proportion)

1995–2004 (Ko et al.) [5]

2005–2013 (Sun et al.)

Second salvage attempt

44.44 % (4.78)

[34.88, 54.32]

50.91 % (3.89)

[43.02, 58.76]

0.0647 (0.0616)

(−0.0561, 0.1855)

p = 0.2955

Third salvage attempt

26.78 % (5.92)

[15.83, 40.30]

36.99 % (5.65)

[25.97, 49.09]

0.1021 (0.0818)

(−0.0583, 0.2624)

p = 0.2200

Fourth through eighth salvage attempt

12.31 % (4.07)

[5.47, 22.82]

30.77 % (6.40)

[18.72, 45.10]

0.1846 (0.0759)

(0.0358, 0.3333)

p = 0.0140

  1. CR complete remission, SE standard error
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