Table 5 Cox proportional hazards model of event-free survival from start of remission for patients who achieved CR after ≥2 salvage attempts (n = 108 patients with 125 attempts)
Variable | Variable levels | Number of events/total | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|
HR | 95% CI | HR | 95% CI | |||
Salvage attempt | Second | 52/82 | 1.0 | – | 1.0 | – |
Third | 24/27 | 1.99 | 1.21–3.26 | 1.78 | 1.06–2.98 | |
Fourth through eighth | 10/16 | 1.31 | 0.67–2.60 | 1.18 | 0.57–2.44 | |
p-value | 0.0323 | 0.1073 | ||||
Trend p-value | 0.0906 | 0.1368 | ||||
Duration of previous remission | CR not achieved | 26/37 | 0.72 | 0.40–1.28 | 0.77 | 0.40–1.47 |
CR < 18 m duration | 21/29 | 1.0 | – | 1.0 | – | |
CR 18–36 m duration | 12/20 | 0.61 | 0.30–1.25 | 0.71 | 0.34–1.49 | |
CR ≥ 36 m duration | 8/16 | 0.41 | 0.18–0.92 | 0.45 | 0.19–1.04 | |
Not evaluable for response | 19/23 | 1.16 | 0.62–2.15 | 1.20 | 0.61–2.36 | |
p-value | 0.1452 | 0.2807 | ||||
Trend p-value | 0.1422 | 0.2211 | ||||
NCI risk category at diagnosis | Non-infants, standard risk | 39/60 | 1.0 | – | 1.0 | – |
Non-infants, high risk | 35/46 | 1.29 | 0.81–2.02 | 1.21 | 0.74–1.97 | |
Non-infants, unknown | 11/17 | 1.08 | 0.55–2.11 | 0.96 | 0.44–2.11 | |
Infants | 1/2 | – | – | – | – | |
p-value | 0.7440 | 0.8127 | ||||
Extramedullary involvement at relapse | No | 72/101 | 1.0 | – | 1.0 | – |
Yes | 14/24 | 0.67 | 0.38–1.19 | 0.71 | 0.38–1.31 | |
p-value | 0.1522 | 0.2644 | ||||
Subsequent HSCT | No | 43/57 | 1.0 | – | 1.0 | – |
Yes | 43/68 | 0.73 | 0.45–1.21 | 0.76 | 0.42–1.36 | |
p-value | 0.2292 | 0.3530 | ||||
BM status at start of attempt | M2 (5–25%) | 18/23 | 1.0 | – | 1.0 | – |
M3 (over 25%) | 68/102 | 0.90 | 0.53–1.51 | 1.14 | 0.65–1.99 | |
p-value | 0.6854 | 0.6500 | ||||
Cytogenetics | Favorable | 17/24 | 1.0 | – | 1.0 | – |
Unfavorable | 14/21 | 1.02 | 0.50–2.07 | 0.53 | 0.22–1.28 | |
Other | 55/80 | 1.08 | 0.68–2.03 | 1.15 | 0.63–2.10 | |
p-value | 0.7802 | 0.0869 | ||||
