Fig. 1
From: Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice
Mice expressing a low dose of Gfi1 develop a fatal myeloproliferative disease. A Survival curves of WT, KI, KD, and KO mice. Mice were considered sick when they showed symptoms such as weight loss, shaking, and impaired mobility. B Weight (left) and spleen index (right) of sick KD mice compared to age-matched WT, KI, and KO mice. C HE staining of spleens from WT, KI, sick KD (sKD), and age-matched old KO (oKO). D Total cell counts of splenic cells and myeloid cell counts in spleen of WT, KI, young KD (yKD), old KD (oKD), young KO (yKO), and old KO (oKO). Orange spots mean sick mice. E Reticulum staining of spleens from WT, KI, sick KD (sKD) and age-matched old KO (oKO). F White blood cell (WBC), red blood cell (RBC), platelets (PLT), hemoglobin levels (HGB), hematocrit (HCT), and blast counts in sick KD and age-matched WT, KI, and KO mice. G Examples of BM cytospins from control old KI mice (a), old KD mice (b), old KD mice starting to be sick (c), and sick old KD mice (d) after MGG staining. Magnification 40 ×.
