Fig. 7
From: Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice
KD mice showed a different p53 signaling profile compare to the KO mice. A Proportions of T-ALL, myeloid leukemia, B-ALL, and solid tumors in sick WT p53-/-, KI p53-/-, KD p53-/-, and KO p53 -/- mice. Mice were considered sick when they showed symptoms such as weight loss, shaking, and less mobility. B Survival curves of sick WT p53-/-, KI p53-/-, KD p53-/-, and KO p53-/- mice developing a myeloid disease. C Representative FACS plots of sick KD p53-/- and KO p53-/- developing a myeloid disease. D Proportions of T-ALL, myeloid leukemia, B-ALL, solid tumors, or no disease in sick WT p53 + /-, KI p53 + /-, KD p53 + /-, and KO p53 + /- mice. Mice were considered sick when they showed symptoms such as weight loss, shaking, and less mobility. E Survival curves of sick WT p53 + /-, KI p53 + /-, KD p53 + /-, and KO p53 + /- mice developing a myeloid disease. F Representative FACS plots of sick KD p53 + /- and KO p53 + /- developing a myeloid disease
