Fig. 2
From: Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options
Schematic overview of genetic and epigenetic abnormalities in Wnt pathway components in MM and drugs that target canonical Wnt signaling. Aberrant canonical Wnt signaling pathway activation in MM cells is facilitated by epigenetic silencing (blue), overexpression (green), or mutation (yellow) of multiple Wnt pathway components. Notably, a variety of antibodies, small molecule, and peptides have been recently developed that target Wnt signaling at multiple distinct levels (red, see also Table 2)
