Fig. 2 | Leukemia

Fig. 2

From: Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Fig. 2

Ikaros functions as a pioneer transcription factor. a Heatmaps of Ikaros ChIP-seq, ATAC-seq, H3K4me1 and H3K27Ac ChIP-seq signals at open chromatin regions gained at day 1 vs. day 0. b Examples of de novo open chromatin regions and associated genes. Ikaros-induced epigenetic changes are shaded in gray. c Motif analysis for de novo open chromatin regions. d De novo open chromatin regions classified by function of the DNA element. e, f Gene ontology and pathway enrichment analysis of genes associated with de novo open chromatin regions

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