Table 1 ERG SNP rs2836371 genotype frequencies in Latino and non-Latino white Down syndrome (DS) ALL cases and DS non-leukemia controls from the International Study of Down Syndrome Acute Leukemia (IS-DSAL), measured by Taqman SNP genotyping

From: Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome

rs2836371 genotype

Latinos

Non-Latino whites

Cases n = 103 (%)

Controls n = 96 (%)

P-value

OR (95% CI)

Cases n = 83 (%)

Controls n = 78 (%)

P-value

OR (95% CI)

TTT

26 (25.2)

34 (35.4)

0.016

1.44 (1.08–1.96)

24 (28.9)

26 (33.3)

0.69

1.07 (0.77–1.49)

TTC

33 (32.0)

35 (36.5)

  

36 (43.4)

30 (38.5)

  

TCC

30 (29.1)

22 (22.9)

  

14 (16.9)

15 (19.2)

  

CCC

14 (13.6)

5 (5.2)

  

9 (10.8)

7 (9.0)

  

Risk allele (C) frequency

0.437

0.326

  

0.365

0.346

  

CCC vs. TTT*

  

0.02

3.66 (1.17–11.47)

  

0.57

1.39 (0.45–4.32)

  1. P values and odds ratios (OR) are calculated using logistic regression tests, assuming the additive model unless specified
  2. *P values and ORs calculated using chi-square tests
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