Fig. 1
From: Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)
BRCC3 mutation status in AML and MDS. a Frequency of BRCC3 mutations found in t(8;21)(q22;q22.1) and inv(16)(p13.1q22) AML in 351 patients [30]. Data for MDS and de novo AML was obtained from Huang et al. [28] and the TCGA AML [29] data set, respectively. b Overview of the BRCC3 coding region with mutations analyzed in t(8;21)(q22;q22.1) AML in our study on top and mutations found in Huang et al. and the TCGA data set below. The metalloprotease (MPN) domain is indicated in blue and the JAB1/MPN/Mov34 metalloenzyme (JAMM) domain in red
