Fig. 3
Correlation of protein and mRNA transcript expression of nuclear proteins changed in AML. a Protein and mRNA expression changes in two transcription factors identified to be differentially expressed between AML blasts and normal human CD34+ cells using LC/LC-MS/MS. Values below one are repressed in AML blasts. Some patients do not have a significant detection of protein when analyzed by LC/LC-MS/MS. b Correlation of nuclear protein expression with mRNA expression in nuclear proteins identified to be significantly changed between AML and CD34+ cells. Legend depicts level of change in protein expression in AML vs. normal CD34+ cells. Negative values depict lower levels of expression in AML vs. CD34+ cells. c Box and whisker plot show relative MS quantitation of S100A4 protein in expression in nuclear AML blasts vs. normal controls (n = 11). The dashed line represents no change to control (CD34+). Solid line indicates median and filled square indicates mean
