Fig. 2: Single-site sampling results in underestimation of total-body leukemia clonal complexity. | Leukemia

Fig. 2: Single-site sampling results in underestimation of total-body leukemia clonal complexity.

From: Quantitative distribution of patient-derived leukemia clones in murine xenografts revealed by cellular barcodes

Fig. 2

a, b Number of (non-)overlapping barcodes in the bone marrow and extramedullary locations. Barcode analysis was restricted to the top 85% most abundant barcodes to prevent false-positive barcode calling. c Number of (non-)overlapping barcodes from the top 85% most abundant barcodes in the blood, pelvis and remaining body. d, e Overall barcode frequency of the top 85% most abundant barcodes that are detected or remain undetected when blood or pelvis was sampled at end-stage leukemia (one representative recipient). Statistical analysis: two-sided Mann–Whitney U test, *p < 0.0001.

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