Table 2 Multivariable analysis for the risk of dying from acute lymphoblastic leukaemia for patients aged < 18 years in the Netherlands between 1990 and 2015.

	N	HR^a	95% CI	P value
Period
1990–94	481	Ref.
1995–99	589	0.9	0.7–1.2	0.56
2000–04	640	0.7	0.5–0.9	0.01
2005–09	585	0.5	0.1–0.3	<0.01
2010–15	702	0.4	0.1–0.3	<0.01
Sex
Male	1744	Ref.
Female	1253	0.9	0.7–1.1	0.19
Age groups (years)
0	90	8.2	5.8–12	<0.01
1–4	1385	Ref.
5–9	796	1	0.8–1.4	0.79
10–14	479	2.1	1.6–2.8	<0.01
15–17	247	3.5	2.6–4.7	<0.01
Immunophenotype
BCP-ALL	2562	Ref.
T-cell ALL	424	1.9	1.5–2.4	<0.01
Unknown	11	ND

BCP-ALL B-cell precursor acute lymphoblastic leukaemia, HR hazard ratio, CI confidence interval, ND not done.
^aIn this multivariable analysis, each covariate is simultaneously adjusted for all other covariates and follow-up time. Hazard ratios represent risk of death within 5 years from diagnosis compared to the reference category.

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