Table 2 Co-variates of cases of COVID-19.

From: COVID-19 in persons with chronic myeloid leukaemia

Case number

1

2

3

4

5

Sex

Female

Male

Female

Male

Female

Age, y

41

47

46

65

89

CML phase at diagnosis

CP

AP

AP

CP

CP

Co-morbidity

Hypertension

None

Diabetes

Hypertension

Coronary heart disease

Interval from diagnosis of CML to diagnosis of COVID-19, mo

0

121

27

23

133

Current TKIa

Flumatinib

HQP1351

Imatinib

Imatinib

Imatinib

TKI response at diagnosis of COVID-19

No CHR

MMR

No CHR

MMR

CCyR

Contact with suspected or confirmed persons

No

No

No

Yes

No

Symptom of onset

 Fever

Yes

Yes

Yes

Yes

No

 Cough

Yes

Yes

No

Yes

Yes

 Dyspnoea

No

No

No

Yes

Yes

 Sore throat

Yes

Yes

No

No

No

 Fatigue

Yes

Yes

Yes

Yes

Yes

 Diarrhoea

No

No

Yes

No

No

Laboratory co-variates

 WBC × 10E+9/L

108.25

4

7.25

2.28

5.13

 Neutrophils × 10E+9/L

89.2

2.61

4.92

1.27

4.5

 Lymphocytes × 10E+9/L

4.75

0.78

0.94

0.58

0.17

 Haemoglobin, g/L

107

96

40

93

72.5

 Platelets × 10E+9/L

487

298

97

297

77.4

Typical findings on lung CT scan

Yes

No

Yes

Yes

Yes

Diagnosis of COVID-19

Confirmed

Confirmed

Confirmed

Confirmed

Probable

Severity of COVID-19

Common

Mild

Common

Common

Critical

Duration from COVID-19 onset to discharge or death, days

34

16

15

47

7

Outcome of COVID-19

Cured

Cured

Cured

Cured

Dead

TKI interruption during COVID-19

No

Yes

Nob

No

No

  1. CML chronic myeloid leukaemia, COVID-19 coronavirus disease 2019, CT computed tomography, mo month(s), TKI tyrosine kinase-inhibitor, y years.
  2. aCase 1 started flumatinib therapy after 14 days of symptom onset of COVID-19.
  3. bCase 3 switched to dasatinib because of imatinib resistance when her lung CT scan was near normal and the SARS-CoV-2 RT-PCR test was negative.