Table 1 Somatic mutations in leukemia-associated genes within a cohort of 50 healthy elderly individuals.
Sample number | Sex, age | Gene | Variant Ensemble | Protein | % Reads displaying variant gDNA | % Reads displaying variant buccal cells | % Reads displaying variant gDNA (2-year follow-up) | % Reads displaying variant gDNA (3-year follow-up) |
|---|---|---|---|---|---|---|---|---|
#5 | Female, 86 | DNMT3A | c.1403A>G | p.K468R | 5.53 | 0.00 | 5.42 | 4.85 |
#9 | Male, 81 | SRSF2 | c.144_169del(26) | p.Y50LfsX11 | 10.63 | 0.46 | 7.12 | 8.33 |
#10 | Male, 86 | SF3B1 | c.2098A>G | p.K700E | 6.56 | 0.00 | † | † |
#15 | Female, 83 | DNMT3A | c.2644C>T | p.R882C | 4.89 | 0.00 | 6.76 | ─ |
DNMT3A | c.2711C>T | p.P904L | 3.60 | 0.00 | 3.54 | ─ | ||
#21 | Male, 85 | IDH2 | c.418C>T | p.R140W | 22.75 | 12.47 | 28.98 | 33.69 |
SRSF2 | c.284C>T | p.P95L | 28.78 | 15.6 | 35.29 | 56.59 | ||
TET2 | c.5618T>C | p.I1873T | 20.41 | 12.74 | 21.80 | 21.51 | ||
#22 | Female, 85 | DNMT3A | c.1988C>T | p.S663W | 1.04 | 0.00 | 1.02 | 0.86 |
#24 | Male, 81 | TP53 | c.638G>A | p.R213Q | 15.43 | 0.90 | 15.70 | 18.50 |
#25 | Male, 81 | DNMT3A | c.2401A>G | p.M801V | 30.69 | 10.82 | 30.04 | 32.15 |
#35 | Female, 86 | NRAS | c.35G>A | p.G12D | 6.19 | 0.39 | 11.72 | ─ |
#37 | Female, 81 | DNMT3A | c.1031T>C | p.L344P | 5.03 | 1.58 | 5.23 | 5.17 |
#41 | Female, 82 | DNMT3A | c.929T>C | p.I310T | 17.82 | 0.00 | 17.26 | 21.60 |
#42 | Male, 85 | U2AF1 | c.101C>T | p.S34F | 23.16 | 1.38 | † | † |
#43 | Female, 81 | DNMT3A | c.1988C>T | p.S663W | 12.67 | 0.00 | 14.38 | 18.80 |
