Table 2 Response characteristics.

From: Long-term activity of tandem CD19/CD20 CAR therapy in refractory/relapsed B-cell lymphoma: a single-arm, phase 1–2 trial

 

Efficacy (95% CI)

Best overall response (all, n = 87)

78% (68–86%)

 Complete response

70% (59–79%)

 Partial response

8% (3–16%)

 Progressive disease

16% (9–26%)

 Could not be evaluated

6% (2–13%)

Ongoing response

61% (44–75%)

Best overall response (aggressive:DLBCL, PMBCL and tFL, n = 69)

75% (64–85%)

 Complete response

68% (56–79%)

 Partial response

7% (2–16%)

 Progressive disease

19% (10–30%)

 Could not be evaluated

6% (2–14%)

Best overall response (DLBCL, n = 58)

78% (65–87%)

 Complete response

71% (57–82%)

 Partial response

7% (2–17%)

 Progressive disease

21% (11–33%)

 Could not be evaluated

2% (0–9%)

Best overall response (FL, n = 13)

92% (64–100%)

 Complete response

77% (46–95%)

 Partial response

15% (2–45%)

 Progressive disease

8% (0–36%)

 Could not be evaluated

0

Response of intent-to-treat (n = 92)

74% (64–83%)

Median duration of response, months (95% CI)

NR (23.4-NE)

Median progression-free survival, months (95% CI)

27.6 (11-NE)

Median overall survival, months (95% CI)

NR (36.7-NE)

  1. All patients who received TanCAR7 T cell infusion were included in the efficacy evaluation. The best overall response rate was calculated as the percentage of patients who had a complete and partial response.
  2. CI confidence interval, DLBCL diffuse large B-cell lymphoma, FL follicular lymphoma, NE could not be estimated, NR not reached, PMBCL primary mediastinal B-cell lymphoma, tFL transformed follicular lymphoma.